Health minister’s advisers urge more research on long Covid
Committee urges patients with long Covid to be vaccinated and to join clinical research programmes to assist in the development of therapies
15 June 2022 - 13:18
byStaff Writer
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As many as one-third of people with mild symptoms experience long Covid, according to the The health minister’s Covid-19 advisory committee. Picture: 123RF/GEORGEEB22
The health minister’s Covid-19 advisory committee has made its first recommendations about long Covid, but conceded that many questions remain about the condition.
In a memo to minister Joe Phaahla dated May 27, committee heads Koleka Mlisana and Marian Jacobs said a study of adults hospitalised with Covid-19 found more than two-thirds reported an incomplete recovery three months after their acute illness.
Long Covid symptoms had also been detected in up to one-third of patients who had mild infections.
“While most symptoms appear to abate over time, the natural history of the condition is not yet known,” they said.
“The impact of long Covid on quality of life can be severe, with significant limitations to social and occupational functioning. These have been found to have a substantial negative impact on quality of life, ability to work and carry out daily activities.
“On average, individuals experiencing long Covid function at 59% of their pre-Covid abilities, and more than 20% of individuals are unable to return to work. Poor quality of life is associated with prior ICU admission and fatigue.”
Risk factors for long Covid include advancing age, being biologically female, pre-existing comorbidities (including obesity, hypertension, diabetes mellitus and asthma), and immunodeficiency (including HIV and cancer).
THE SYMPTOMS
Fatigue, breathlessness, cognitive difficulties, muscle and joint pain, headache, persistent cough, chest pain, anxiety, depression and sleep disturbance are common symptoms of long Covid, according to the ministerial advisory committee
However, Mlisana and Jacobs said: “There are presently no registered or evidence-based therapeutic interventions available for treatment of long Covid. There is no widely accepted definition for the condition in children.”
In the absence of evidence-based clinical guidelines or treatments, the advisory committee recommended a series of tests doctors can use to diagnose long Covid and said: “Treatment strategies should be guided by the individual clinical presentation, and aimed at ameliorating symptoms until more directed therapies are available.
“Identification and optimisation of the management of existing comorbidities, new comorbidities and complications of acute Covid-19 are important goals in the management of patients with long Covid.”
The experts encouraged patients with long Covid to be vaccinated and to join clinical research programmes “to permit the generation of local data and provide access to emerging therapies”.
“Establishing multi-disciplinary specialist clinics (or clinics with the potential for specialist interdisciplinary collaboration/referral) will be needed for the assessment and management of complex cases on a referral basis. Regional clinical experts should be identified to lead such efforts.”
The committee also suggested long Covid should be recognised as a medical condition by the health department, which should lead the effort to develop evidence-based clinical guidelines for the condition.
“The National Institute for Communicable Diseases should be requested to establish a surveillance system to establish the incidence and prevalence of long Covid,” it said.
The experts also recommended:
the health department prepare courses on long Covid for doctors;
the College of Medicine be approached to consider a diploma in the management of Covid and long Covid; and
the SA Medical Research Council be asked to issue a call for proposals looking at the epidemiology, pathophysiology, diagnosis and management of long Covid.
Support our award-winning journalism. The Premium package (digital only) is R30 for the first month and thereafter you pay R129 p/m now ad-free for all subscribers.
Health minister’s advisers urge more research on long Covid
Committee urges patients with long Covid to be vaccinated and to join clinical research programmes to assist in the development of therapies
The health minister’s Covid-19 advisory committee has made its first recommendations about long Covid, but conceded that many questions remain about the condition.
In a memo to minister Joe Phaahla dated May 27, committee heads Koleka Mlisana and Marian Jacobs said a study of adults hospitalised with Covid-19 found more than two-thirds reported an incomplete recovery three months after their acute illness.
Long Covid symptoms had also been detected in up to one-third of patients who had mild infections.
“While most symptoms appear to abate over time, the natural history of the condition is not yet known,” they said.
“The impact of long Covid on quality of life can be severe, with significant limitations to social and occupational functioning. These have been found to have a substantial negative impact on quality of life, ability to work and carry out daily activities.
“On average, individuals experiencing long Covid function at 59% of their pre-Covid abilities, and more than 20% of individuals are unable to return to work. Poor quality of life is associated with prior ICU admission and fatigue.”
Risk factors for long Covid include advancing age, being biologically female, pre-existing comorbidities (including obesity, hypertension, diabetes mellitus and asthma), and immunodeficiency (including HIV and cancer).
THE SYMPTOMS
Fatigue, breathlessness, cognitive difficulties, muscle and joint pain, headache, persistent cough, chest pain, anxiety, depression and sleep disturbance are common symptoms of long Covid, according to the ministerial advisory committee
However, Mlisana and Jacobs said: “There are presently no registered or evidence-based therapeutic interventions available for treatment of long Covid. There is no widely accepted definition for the condition in children.”
In the absence of evidence-based clinical guidelines or treatments, the advisory committee recommended a series of tests doctors can use to diagnose long Covid and said: “Treatment strategies should be guided by the individual clinical presentation, and aimed at ameliorating symptoms until more directed therapies are available.
“Identification and optimisation of the management of existing comorbidities, new comorbidities and complications of acute Covid-19 are important goals in the management of patients with long Covid.”
The experts encouraged patients with long Covid to be vaccinated and to join clinical research programmes “to permit the generation of local data and provide access to emerging therapies”.
“Establishing multi-disciplinary specialist clinics (or clinics with the potential for specialist interdisciplinary collaboration/referral) will be needed for the assessment and management of complex cases on a referral basis. Regional clinical experts should be identified to lead such efforts.”
The committee also suggested long Covid should be recognised as a medical condition by the health department, which should lead the effort to develop evidence-based clinical guidelines for the condition.
“The National Institute for Communicable Diseases should be requested to establish a surveillance system to establish the incidence and prevalence of long Covid,” it said.
The experts also recommended:
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