London/New York — Barclays CEO Jes Staley is being investigated over his ties to disgraced financier Jeffrey Epstein, his second run-in with British regulators since he joined the bank in 2015.

The bank said regulators are probing how Staley characterised his relationship with Epstein, the convicted sex offender who died in his prison cell last year. The newest probe is another distraction for Barclays as it faces additional challenges to meet its profit goals. In 2018, Staley was fined for his attempts to uncover a whistle-blower...

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