London — Prime Minister Boris Johnson’s coronavirus strategy descended into disarray three days after it was announced, as local leaders rejected his regional approach and UK government scientists pushed for an emergency national lockdown to slow the rate of infections.

London will face tighter restrictions from Saturday, with a ban on households mixing indoors, but political leaders in Manchester, northern England, are now in open revolt, refusing Johnson’s request to move to the highest level of pandemic curbs unless he provides more generous financial support...

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