London — The EU is on course for a clash with British Prime Minister Boris Johnson after European Commission president Ursula von der Leyen warned it will be “impossible” to get a full deal before his year-end deadline.

In her first major intervention on Brexit since she took up her post on December 1, Von der Leyen said the EU is “ready to work day and night” to strike a deal but warned Johnson that there isn’t time for detailed negotiations on all aspects of the UK’s future relationship with the EU...

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