Washington/New York — The US Securities and Exchange Commission’s (SEC) new enforcement head abruptly resigned on  Wednesday, citing a complication in a case from her prior legal career, an early and significant setback in chair Gary Gensler’s tenure running the Wall Street regulator.

Alex Oh’s surprise move, announced just a week after she got the job, means Gensler won’t have his preferred pick leading what’s arguably the agency’s most important division. Melissa Hodgman, who was previously serving as acting director of the enforcement division, will return to that role, the SEC said in a statement...

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