Mexico City — The US has had a long love affair with distilled drinks made from agave. First came the tequila craze, then smoky mescal was all the rage. Now entrepreneurs, eager to tap into the reopening of bars and restaurants across the US, are banking on a new drink they’re calling avila.

Revel Spirts, a closely held company based in Los Angeles, California, has a simple concept: take the same blue agave used in tequila, cultivate it in the state of Morelos and distil it using the artisanal method of slow-cooking over burning wood that produces smoky-accented mescal...

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