Manchester — Manchester City take a 2-1 lead into their Champions League last-16 match against Real Madrid at the Etihad Stadium on Friday, but manager Pep Guardiola needs no reminders of how quickly games can turn in Europe’s elite competition.

In 2019’s quarterfinals City went out on away goals to Tottenham Hotspur after looking in command when 4-2 up in the second leg. The previous year, City were blitzed by three Liverpool goals inside 19 first-half minutes as they fell to a 5-1 aggregate defeat...

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