Washington — After a litany of prescriptions failed to control her stormy mood swings and deep depression, writer Ayelet Waldman finally found relief in a blue vial of diluted LSD.

Feeling she "had nothing to lose," the San Francisco Bay-area former federal public defender deposited two tiny drops of the psychedelic drug under her tongue — and soon felt her gloom subside.

"I was starting to feel, frankly, suicidal," she said. "If the other option is death — or at least, misery that feels like death — then there’s no reason not to at least try something different."

Waldman says she renewed her spirit by "microdosing", a modish — albeit illegal and potentially risky — trend that involves ingesting a nearly imperceptible portion of a psychedelic drug, often LSD or psilocybin mushrooms.

The goal is not to hallucinate but to boost work performance and creativity — or, as was Waldman’s case, treat a laundry list of ailments including mood disorders.

"Within the first day I felt better," she said. "The depression was just gone — and that was astonishing." She credits her daily LSD regimen of some 10 micrograms of acid — about one-tenth of a full, far more kaleidoscopic hit — with improving her relationships and enhancing her work.

"I would have access to ‘that flow’," she said, describing how subtle doses of LSD changed her writing habits. "Your mind moves swiftly but not erratically, with a kind of really delightful focus."

Microdosing has gained traction outside drug-enthusiast circles in recent years, particularly among young professionals in California’s Silicon Valley looking to dial up their careers.

Its growing popularity has been ushered along by several influential US podcasts and most recently Waldman’s latest book, "A Really Good Day: How Microdosing Made a Mega Difference in My Mood, My Marriage, and My Life," in which she details how psychedelics helped her.

LSD, or lysergic acid diethylamide, is a potent synthetic drug that gained notoriety in 1960s counterculture. In large doses it can induce hallucinations and drastically alter perception and cognitive functions for prolonged periods of time.

Carl, whose name has been changed for fear of legal repercussions, works in media in Washington and says he has microdosed with LSD at work half-a-dozen times in the past year.

He said the tiny hits helped him stay focused.

"You’ve got more energy," he said. "The core of your consciousness is still there — you just might be a little bit more in touch."

Oliver, whose name has also been changed, described dropping microdoses as a "very mild euphoria — almost like anticipation of something good". The 25-year-old, who is also a media professional in Washington DC, has taken recreational tabs of acid — which he said have cost about $10 each — in addition to tiny doses.

Rather than a full psychedelic experience, he said microdosing gives him "a slight sharpening of concentration, I think produced by the effect that LSD has of making everything feel textured and interesting".

"I felt not on top of the world, but 1% more on top of the world than usual," he said. "Which kind of made me feel like I wanted to work."

Oliver said he thought of microdosing as "a cop-out way of doing psychedelics".

"It’s much less threatening," he said wryly. "And is less likely to … cause temporary ego death, or make you spiral into soul-crushing confusion over the changing colour of the sky."

While microdosing has shown anecdotal medicinal and performance-enhancing promise, potential risks such as long-term toxicity, remain unclear, said Matthew Johnson, who studies drug abuse and addiction at Johns Hopkins University.

Microdosing is "totally unstudied" for both funding and legal reasons, he said. LSD was first criminalised in 1966, and in 1970, the US government grouped it, along with psilocybin, in the most legally restrictive category of substances alongside drugs such as heroin and mescaline.

That classification brought mid-century studies on using psychedelics as medicine to a standstill.

Obvious hazards include ingesting street drugs cut with harmful substances or incorrectly controlling dosage, Johnson said.

And because intended doses are so small, perceived positive effects might actually be placebo effects.

Still, he said, microdosing warrants controlled study as "it’s absolutely interesting and very plausible that there could be effects of cognitive enhancement and antidepression".

His own studies have yielded encouraging outcomes using psilocybin to help cancer patients manage anxiety and depression, or to help tobacco smokers quit.

In general, he said, researchers focused on psychedelics say overregulation is hindering progress.

The legal gamble ultimately dissuaded Waldman from continuing to microdose. She received her initial 30-day LSD supply from a friend of a friend — but procuring more proved nerve wracking.

Drug penalties vary state by state, but are often similar to the federal ones: up to a year in jail and a $1,000 fine for a first offence of LSD possession.

As a former lawyer who has defended clients on drug charges, Waldman said she could not justify the risk.

Until LSD is legalised — unlikely anytime soon — she said she probably would not microdose again.

Unless, Waldman said, "I start to become suicidal again." If the choice is "to die or commit a crime, I’ll commit a crime".


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