It’s truly the end of the old Microsoft. Late on Friday, co-founder and original CEO Bill Gates, the man most closely identified with the world’s largest software maker, said he will leave the company’s board to devote more time to his charitable foundation, which is playing a key role in global health initiatives and expanding into new areas such as climate change.

Gates will remain as a technical adviser to the company, helping to guide CEO Satya Nadella and senior leadership on issues such as the future of productivity software, health-care technology and artificial intelligence...

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