Danish investors and analysts spent their morning trying to figure out why a tiny biotechnology company suddenly soared almost 1,400% during US trading hours.

Orphazyme A/S says it has no idea why its American depositary shares surged overnight. When trading started in Copenhagen on Friday, the stock initially rose as much as 76%, before jumping more than 140% when the US opened later in the day. The company warned investors against being sucked into the frenzy...

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