San Francisco/Seattle — Amazon’s talks to buy driverless vehicle start-up Zoox has analysts speculating the deal could save the e-commerce giant tens of billions a year and put vehicle, parcel and ride-hailing companies on their heels.

Shipping costs are one of Amazon’s largest expenses and may reach $90bn in the coming years, Morgan Stanley’s internet, automotive and transport analysts wrote in a report on Wednesday. An autonomous offering could save the company more than $20bn annually, they estimate...

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